Title : The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance.

Pub. Date : 2003 Sep 1

PMID : 14500394






1 Functional Relationships(s)
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1 The results also demonstrate that CDDO-induced: (a) stimulation of Jun NH(2)-terminal kinase; (b) activation of caspase-8; (c) loss of mitochondrial transmembrane potential; (d) release of cytochrome c; and (e) cleavage of caspase-3 are blocked by pretreatment with the antioxidant N-acetyl-L-cysteine and GSH but not with cysteine. 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid caspase 3 Homo sapiens