Pub. Date : 2003 Oct
PMID : 14500041
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Atorvastatin reduces interleukin-6 plasma concentration and adipocyte secretion of hypercholesterolemic rabbits. | Atorvastatin | interleukin-6 | Oryctolagus cuniculus |
| 2 | The in vitro effect of atorvastatin on IL-6 production in adipocytes was observed. | Atorvastatin | interleukin-6 | Oryctolagus cuniculus |
| 3 | RESULTS: Two weeks atorvastatin treatment resulted in significant reduction of circulating IL-6 concentrations, which was associated with IL-6 secretion in adipocytes (r=0.849, P<0.01). | Atorvastatin | interleukin-6 | Oryctolagus cuniculus |
| 4 | RESULTS: Two weeks atorvastatin treatment resulted in significant reduction of circulating IL-6 concentrations, which was associated with IL-6 secretion in adipocytes (r=0.849, P<0.01). | Atorvastatin | interleukin-6 | Oryctolagus cuniculus |
| 5 | Atorvastatin induced the decreased IL-6 secretion in dose-dependent manner. | Atorvastatin | interleukin-6 | Oryctolagus cuniculus |
| 6 | CONCLUSIONS: Atorvastatin can inhibit IL-6 secretion in adipocytes possibly through upregulating PPARgamma, which may help to explain the anti-inflammatory effects of statins use. | Atorvastatin | interleukin-6 | Oryctolagus cuniculus |