Title : Sustained and transient downregulation of Src kinases in response to nerve growth factor and epidermal growth factor, respectively.

Pub. Date : 2003 Nov

PMID : 14499346






2 Functional Relationships(s)
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1 By probing total cell extracts and anti-P-Tyr immunoprecipitates with a phosphorylation site-specific antibody targeting a conserved site of positive regulation of the overall family of Src kinases, a sustained and a transient downregulation of the immunoprecipitable subpopulation of nominally active Src kinases is detected in response to NGF and EGF, respectively. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
2 By probing total cell extracts and anti-P-Tyr immunoprecipitates with a phosphorylation site-specific antibody targeting a conserved site of positive regulation of the overall family of Src kinases, a sustained and a transient downregulation of the immunoprecipitable subpopulation of nominally active Src kinases is detected in response to NGF and EGF, respectively. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus