Pub. Date : 1992 Nov
PMID : 1425417
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Addition of IL-1 to macrophage-depleted primary cultures of mouse Leydig cells caused a dose-dependent decrease in cAMP-dependent testosterone production and 17 alpha-hydroxylase/C17-20 lyase (P450c17) mRNA levels. | Cyclic AMP | interleukin 1 complex | Mus musculus |
| 2 | IL-1 caused a dose-dependent decrease in 8-Br-cAMP-stimulated P450c17 levels (0.2 U/ml by 31 +/- 9%, 2 U/ml by 82 +/- 12%, and 10 or 20 U/ml by 100% compared to that in cells treated with 8-Br-cAMP alone). | Cyclic AMP | interleukin 1 complex | Mus musculus |
| 3 | The inhibitory effect of IL-1 on 8-Br-cAMP-stimulated P450c17 expression was reversible. | Cyclic AMP | interleukin 1 complex | Mus musculus |