Title : Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Pub. Date : 1992 Nov

PMID : 1423885






2 Functional Relationships(s)
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1 The aim of this study was to determine whether there was a correlation between the persistence of O6-methylguanine (O6-mGua) adducts and the rate of recovery of O6-methylguanine-DNA methyltransferase (O6-mGuaT) after depletion in the liver and susceptibility to NNK in F344 rat and Syrian golden hamster injected s.c. with NNK (80 mg/kg). 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone O-6-methylguanine-DNA methyltransferase Rattus norvegicus
2 The aim of this study was to determine whether there was a correlation between the persistence of O6-methylguanine (O6-mGua) adducts and the rate of recovery of O6-methylguanine-DNA methyltransferase (O6-mGuaT) after depletion in the liver and susceptibility to NNK in F344 rat and Syrian golden hamster injected s.c. with NNK (80 mg/kg). 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone O-6-methylguanine-DNA methyltransferase Rattus norvegicus