Title : Posttreatment with sodium arsenite alters the mutational spectrum induced by ultraviolet light irradiation in Chinese hamster ovary cells.

Pub. Date : 1992

PMID : 1396606






3 Functional Relationships(s)
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1 However, posttreatment of ultraviolet light (UV) irradiated cells with sodium arsenite synergistically enhances the mutation frequency on the hypoxanthine (guanine) phosphoribosyltransferase locus. sodium arsenite hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus
2 To investigate the molecular mechanism of the comutagenic effects of sodium arsenite, we characterized the alterations of nucleotide sequences in 30 UV-induced and 39 sodium arsenite enhanced hprt mutants from Chinese hamster ovary K1 cells by direct sequencing of mRNA-PCR amplified cDNA. sodium arsenite hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus
3 To investigate the molecular mechanism of the comutagenic effects of sodium arsenite, we characterized the alterations of nucleotide sequences in 30 UV-induced and 39 sodium arsenite enhanced hprt mutants from Chinese hamster ovary K1 cells by direct sequencing of mRNA-PCR amplified cDNA. sodium arsenite hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus