Title : The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.

Pub. Date : 1992 Sep 1

PMID : 1380976






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 FK-506 is known to interact with FK-binding protein-12 (FKBP-12), an abundant cytosolic protein with cis-trans peptidyl-prolyl isomerase activity (PPIase) activity. Tacrolimus FKBP prolyl isomerase 1A Rattus norvegicus
2 FK-506 is known to interact with FK-binding protein-12 (FKBP-12), an abundant cytosolic protein with cis-trans peptidyl-prolyl isomerase activity (PPIase) activity. Tacrolimus FKBP prolyl isomerase 1A Rattus norvegicus
3 Recently, it was found that the complex of FKBP-12 with FK-506, but not with RAP, inhibits the phosphatase activity of calcineurin. Tacrolimus FKBP prolyl isomerase 1A Rattus norvegicus