Title : Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors.

Pub. Date : 1992 Jul

PMID : 1378092






1 Functional Relationships(s)
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1 The EC50 values for I-BOP-induced rise in intracellular free calcium (control = 10.2 +/- 1.5 nM; desensitized = 79.4 +/- 22.4 nM, n = 6, P less than .05), aggregation (control = 15.8 +/- 2.4 nM; desensitized = 51.7 +/- 11.9 nM; P less than .05, n = 5) and shape change (control = 172 +/- 37 pM; desensitized = 350 +/- 60 pM; P less than .05, n = 7) were increased by the preincubation with U46619. Calcium BOP Homo sapiens