Pub. Date : 1992 Jun
PMID : 1375326
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A mutation of the amino-terminal site of myristylation (glycine 2), which prevents stable association of p56lck with the plasma membrane, completely abolished the ability of F505 p56lck to enhance TCR-induced tyrosine protein phosphorylation. | Tyrosine | T cell receptor alpha variable 6-3 | Mus musculus |
| 2 | Alteration of the major site of in vitro autophosphorylation, tyrosine 394, to phenylalanine diminished the enhancement of TCR-induced tyrosine protein phosphorylation by F505 p56lck. | Tyrosine | T cell receptor alpha variable 6-3 | Mus musculus |
| 3 | Strikingly, deletion of the noncatalytic Src homology domain 2, but not of the Src homology domain 3, markedly reduced the improvement of TCR-induced tyrosine protein phosphorylation by F505 Lck. | Tyrosine | T cell receptor alpha variable 6-3 | Mus musculus |
| 4 | Finally, it was also observed that expression of F505 p56lck greatly increased TCR-induced tyrosine phosphorylation of phospholipase C-gamma 1, raising the possibility that phospholipase C-gamma 1 may be a substrate for p56lck in T lymphocytes. | Tyrosine | T cell receptor alpha variable 6-3 | Mus musculus |