Title : CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.

Pub. Date : 1992 Apr 1

PMID : 1372020






5 Functional Relationships(s)
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1 CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling. Tyrosine CD2 molecule Homo sapiens
2 We show that stimulation of CD2 receptors on T cells caused tyrosine phosphorylation of PLC gamma 1. Tyrosine CD2 molecule Homo sapiens
3 Cross-linking of CD2 with CD3 receptors augmented the phosphorylation of PLC gamma 1 on tyrosine, whereas ligation of the CD45 tyrosine phosphatase with CD2 receptors prevented PLC gamma 1 tyrosine phosphorylation. Tyrosine CD2 molecule Homo sapiens
4 Cross-linking of CD2 with CD3 receptors augmented the phosphorylation of PLC gamma 1 on tyrosine, whereas ligation of the CD45 tyrosine phosphatase with CD2 receptors prevented PLC gamma 1 tyrosine phosphorylation. Tyrosine CD2 molecule Homo sapiens
5 CD3 receptor modulation potently down-regulated CD2-induced PLC gamma 1 tyrosine phosphorylation and calcium mobilization. Tyrosine CD2 molecule Homo sapiens