Title : Effect of adenosine analogues and cAMP-raising agents on TNF-, GM-CSF-, and chemotactic peptide-induced degranulation in single adherent neutrophils.

Pub. Date : 1992 Mar

PMID : 1371803






2 Functional Relationships(s)
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1 The phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) at 300 microM reduced fMLP-induced degranulation, whereas a concentration of 1 mM was required to inhibit TNF- and GM-CSF-mediated secretion. 1-Methyl-3-isobutylxanthine tumor necrosis factor Homo sapiens
2 However, in combination with IBMX (300 microM), forskolin (50 microM) reduced both TNF- and fMLP-induced secretion to less than 10%. 1-Methyl-3-isobutylxanthine tumor necrosis factor Homo sapiens