Pub. Date : 1992 Mar 15
PMID : 1371788
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have studied the impact of gangliosides on the expression of TNF in blood monocytes and in the monocytic cell line Mono Mac 6. | Gangliosides | tumor necrosis factor | Homo sapiens |
| 2 | Looking at highly purified gangliosides, GD3, GD1a, GM3, GM2, and GM1 were all effective in reducing TNF production in PBMC, and in Mono Mac 6 by factor 10 to 50. | Gangliosides | tumor necrosis factor | Homo sapiens |
| 3 | Gangliosides appear to act at an early step of activation in that TNF transcripts were reduced and the mobilization of the nuclear factor kappa B was blocked. | Gangliosides | tumor necrosis factor | Homo sapiens |
| 4 | Finally, when using Staphylococcus aureus or platelet activating factor as a stimulus, gangliosides were able to suppress TNF production in Mono Mac 6 cells by factor 5 to 10, as well. | Gangliosides | tumor necrosis factor | Homo sapiens |
| 5 | Taken together, our data demonstrate that TNF gene expression in monocytes induced by different types of stimuli can be blocked by gangliosides at an early step of signal transduction. | Gangliosides | tumor necrosis factor | Homo sapiens |