Title : Mutations in Saccharomyces cerevisiae sterol C5-desaturase conferring resistance to the CYP51 inhibitor fluconazole.

Pub. Date : 2003 Oct 3

PMID : 13679073






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 One mechanism, observed first in Saccharomyces cerevisiae, was through defective sterol C5-desaturase (Erg3p) required to form the fungistatic sterol end-product resulting from CYP51 inhibition, 14alpha-methylergosta-8,24(28)-dien-3beta,6alpha-diol. Sterols C-5 sterol desaturase Saccharomyces cerevisiae S288C