Title : Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies.

Pub. Date : 1991 Mar

PMID : 1364851






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]bradykinin) is a new bradykinin (BK)-antagonist. thi5 kininogen 1 Bos taurus
2 In isolated organ preparations Hoe 140 and D-Arg-[Hyp2,Thi5,8, D-Phe7]BK inhibited bradykinin-induced contractions concentration dependently, with IC50-values in the guinea-pig ileum preparation of 1.1 x 10(-8) mol l-1 and 3 x 10(-5) mol l-1, respectively. thi5 kininogen 1 Bos taurus