Pub. Date : 1992 Dec
PMID : 1361719
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Divergent effects of taxol on tumor necrosis factor-alpha-mediated cytolysis of ovarian carcinoma cells. | Paclitaxel | tumor necrosis factor | Homo sapiens |
| 2 | OBJECTIVE: Our objective was to study the combined effect of taxol and tumor necrosis factor-alpha on the cytolysis of human ovarian carcinoma cell lines, because taxol has been shown to be active against ovarian carcinoma and has also been shown to increase tumor necrosis factor-alpha release from macrophages. | Paclitaxel | tumor necrosis factor | Homo sapiens |
| 3 | RESULTS: At therapeutic concentrations taxol caused a significant increase in tumor necrosis factor-alpha-mediated cytolysis of Caov-3 and A2780 (p < or = 0.05). | Paclitaxel | tumor necrosis factor | Homo sapiens |
| 4 | By contrast, taxol caused a decrease in the tumor necrosis factor-alpha-mediated cytolysis of SK-OV-3 and NIH:OVCAR-3 (p < or = 0.01). | Paclitaxel | tumor necrosis factor | Homo sapiens |