Pub. Date : 1992 May
PMID : 1349649
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Microinjection of the D2 agonist quinpirole into the A10 dopamine region blocks amphetamine-, but not cocaine-stimulated motor activity. | Amphetamine | immunoglobulin kappa variable 6D-21 (non-functional) | Homo sapiens |
| 2 | In a previous report, we demonstrated that intra-A10 injections of baclofen, a gamma-aminobutyric acidB agonist, could inhibit the motor-stimulant response to cocaine and amphetamine. | Amphetamine | immunoglobulin kappa variable 6D-21 (non-functional) | Homo sapiens |
| 3 | In order to further extend these results, we examined the effects of injection of the D2 agonist quinpirole into the A10 region on cocaine- and amphetamine-stimulated motor activity. | Amphetamine | immunoglobulin kappa variable 6D-21 (non-functional) | Homo sapiens |
| 4 | In addition, an intra-A10 injection of 0.3 nmol/microliter quinpirole, a dose chosen for its near threshold effect, could block the motor-stimulant response to a low dose of amphetamine (0.5 mg/kg) and attenuate the response to moderate doses (1.0 and 2.0 mg/kg). | Amphetamine | immunoglobulin kappa variable 6D-21 (non-functional) | Homo sapiens |
| 5 | It is suggested that the different mechanisms of action of cocaine and amphetamine, uptake blocker vs. releaser or longloop vs. shortloop feedback inhibition of A10 dopamine neurons, respectively, may account for the differential effects that quinpirole had in blocking the motor-stimulant response to these psychostimulants. | Amphetamine | immunoglobulin kappa variable 6D-21 (non-functional) | Homo sapiens |