Title : Elevated cAMP is required for stimulation of eicosanoid synthesis by interleukin 1 and bradykinin in BALB/c 3T3 fibroblasts.

Pub. Date : 1992 Jun

PMID : 1338333






4 Functional Relationships(s)
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Protein Name
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1 In Swiss 3T3 murine fibroblasts, interleukin 1 (IL-1) and bradykinin stimulate prostaglandin E2 (PGE2) synthesis. Dinoprostone interleukin 1 complex Mus musculus
2 In Swiss 3T3 murine fibroblasts, interleukin 1 (IL-1) and bradykinin stimulate prostaglandin E2 (PGE2) synthesis. Dinoprostone interleukin 1 complex Mus musculus
3 When BALB/c 3T3 cells were preincubated with cAMP analogs, both IL-1 and bradykinin stimulated PGE2 synthesis to levels similar to those observed in Swiss 3T3 cells. Dinoprostone interleukin 1 complex Mus musculus
4 In these cells, IL-1 and bradykinin stimulated PGE2 synthesis despite basal intracellular cAMP concentrations similar to BALB/c, and cAMP only modestly potentiated the response. Dinoprostone interleukin 1 complex Mus musculus