Pub. Date : 1992
PMID : 1334036
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Platelet activating factor stimulates and primes the liver, Kupffer cells and neutrophils to release superoxide anion. | Superoxides | PCNA clamp associated factor | Rattus norvegicus |
| 2 | This study examines the direct and priming effects of PAF on superoxide anion release by perfused liver, isolated Kupffer cells and blood neutrophils. | Superoxides | PCNA clamp associated factor | Rattus norvegicus |
| 3 | One hour after PAF infusion at a dose of 2.2 micrograms/kg body weight a significant amount of superoxide release (0.71 +/- 0.1 nmol/min/g liver) was measured in the perfused liver compared with the control livers (0.2 +/- 0.01). | Superoxides | PCNA clamp associated factor | Rattus norvegicus |
| 4 | In the in vitro presence of either phorbol ester or opsonized zymosan, superoxide release following PAF treatment in vivo was significantly increased to 1.36 +/- 0.2 and 4.29 +/- 0.36, respectively. | Superoxides | PCNA clamp associated factor | Rattus norvegicus |
| 5 | PAF added in vitro to the perfused livers, isolated Kupffer cells or neutrophils from normal animals stimulated the release of superoxide with or without the above agonists. | Superoxides | PCNA clamp associated factor | Rattus norvegicus |
| 6 | The direct stimulatory effect of PAF on superoxide release was inhibited by the PAF receptor antagonist in vitro. | Superoxides | PCNA clamp associated factor | Rattus norvegicus |
| 7 | The direct stimulatory effect of PAF on superoxide release was inhibited by the PAF receptor antagonist in vitro. | Superoxides | PCNA clamp associated factor | Rattus norvegicus |
| 8 | The role of PAF in the LPS-induced superoxide release by the perfused liver was also examined by the administration of PAF antagonist in endotoxic rats. | Superoxides | PCNA clamp associated factor | Rattus norvegicus |
| 9 | These results indicate that PAF stimulates and primes the hepatic elements to release superoxide. | Superoxides | PCNA clamp associated factor | Rattus norvegicus |