Title : Second messenger systems stimulated by bradykinin in osteoblastic cells: evidence for B2 receptors.

Pub. Date : 1992 Jul

PMID : 1330138






3 Functional Relationships(s)
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1 In all cell types, bradykinin (1 nM-100 microM) caused significant time- and dose-dependent changes in the levels of inositol phosphates. Inositol Phosphates kininogen 1 Homo sapiens
2 Neomycin inhibited the inositol phosphate response to bradykinin, while indomethacin had no effect. Inositol Phosphates kininogen 1 Homo sapiens
3 In addition, the bradykinin-stimulated inositol phosphate response was unaffected by des-Arg9-[Leu8]-bradykinin, a B1 receptor antagonist, while it was inhibited by D-Arg-[Hyp3-[beta-(2-thienyl)-Ala]5,8-D-Phe7]-bradykinin, a B2 receptor antagonist. Inositol Phosphates kininogen 1 Homo sapiens