Title : Endothelin-1 stimulates chloride and potassium secretion in rabbit descending colon.

Pub. Date : 1992 Jun

PMID : 1326745






2 Functional Relationships(s)
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1 ET-1-induced Cl- secretion is completely inhibited by the loop diuretic bumetanide and by indomethacin and quinacrine, inhibitors of prostaglandin synthesis. Prostaglandins endothelin-1 Oryctolagus cuniculus
2 It is concluded that ET-1 causes Cl- and K+ secretion by stimulating phospholipase A2 and release of prostaglandins, whereas Na+ transport is not altered. Prostaglandins endothelin-1 Oryctolagus cuniculus