Pub. Date : 1992 Jan
PMID : 1317225
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of captopril on the release of the components of the renin-angiotensin system into plasma and lymph. | Captopril | renin | Canis lupus familiaris |
| 2 | UNLABELLED: The effects of captopril on the intrarenal renin-angiotensin system were assessed from measurements in arterial plasma, renal venous plasma, and renal lymph from salt-depleted dogs. | Captopril | renin | Canis lupus familiaris |
| 3 | Although captopril increased the secretion of active renin into renal venous plasma by six-fold, the secretion of total renin was unchanged because of a reciprocal fall in the secretion of inactive renin. | Captopril | renin | Canis lupus familiaris |
| 4 | IN CONCLUSION: (1) all components of the renin-angiotensin system are represented in the renal interstitium, as reflected in lymph; (2) Ang II concentrations in renal lymph in vivo approximate arterial levels; (3) increased secretion of active renin into plasma during intrarenal infusion of captopril into denervated kidneys is due predominantly to renin activation; and (4) renal vascular resistance may depend on the concentration of Ang II in the renal interstitium. | Captopril | renin | Canis lupus familiaris |