Pub. Date : 1992 May
PMID : 1317101
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The phorbol ester phorbol 12-myristate-13 acetate (PMA) led to a concentration-dependent inhibition of basal and stimulated EPO formation (ED50 10 nM). | Tetradecanoylphorbol Acetate | erythropoietin | Homo sapiens |
| 2 | The phorbol ester phorbol 12-myristate-13 acetate (PMA) led to a concentration-dependent inhibition of basal and stimulated EPO formation (ED50 10 nM). | Tetradecanoylphorbol Acetate | erythropoietin | Homo sapiens |
| 3 | This decrease of EPO production, which was apparent already after 1 h of incubation with PMA, reached its maximal effect after 24 h and held on for 72 h. It was paralleled by an inhibition of the increase of EPO mRNA levels in response to stimulation. | Tetradecanoylphorbol Acetate | erythropoietin | Homo sapiens |
| 4 | This decrease of EPO production, which was apparent already after 1 h of incubation with PMA, reached its maximal effect after 24 h and held on for 72 h. It was paralleled by an inhibition of the increase of EPO mRNA levels in response to stimulation. | Tetradecanoylphorbol Acetate | erythropoietin | Homo sapiens |
| 5 | Recovery of EPO synthesis after removal of PMA took 48-72 h. The effect of PMA on EPO production was mimicked by phorbol 12,13-dibutyrate (ED50 1 microM) but not by 4 alpha-phorbol 12,13-didecanoate. | Tetradecanoylphorbol Acetate | erythropoietin | Homo sapiens |
| 6 | Recovery of EPO synthesis after removal of PMA took 48-72 h. The effect of PMA on EPO production was mimicked by phorbol 12,13-dibutyrate (ED50 1 microM) but not by 4 alpha-phorbol 12,13-didecanoate. | Tetradecanoylphorbol Acetate | erythropoietin | Homo sapiens |
| 7 | Recovery of EPO synthesis after removal of PMA took 48-72 h. The effect of PMA on EPO production was mimicked by phorbol 12,13-dibutyrate (ED50 1 microM) but not by 4 alpha-phorbol 12,13-didecanoate. | Tetradecanoylphorbol Acetate | erythropoietin | Homo sapiens |