Title : Cytokine-induced (interleukins-3, -6 and -8 and tumour necrosis factor-beta) activation and deactivation of human neutrophils.

Pub. Date : 1992 Feb

PMID : 1312995






3 Functional Relationships(s)
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1 However, the cytokines affected the formyl-methionyl-leucyl-phenylalanine-(FMLP)-induced formation of leukotrienes in a time-dependent manner. Leukotrienes formyl peptide receptor 1 Homo sapiens
2 Preincubation of the cells with the different cytokines for short periods (15 seconds at 37 degrees) enhanced the subsequent FMLP-induced leukotriene generation, whereas preincubation for prolonged times resulted in a reduced formation of leukotrienes. Leukotrienes formyl peptide receptor 1 Homo sapiens
3 The present study indicates a modulation of the FMLP-induced leukotriene formation by diverse cytokines via interaction with the GTP-binding proteins. Leukotrienes formyl peptide receptor 1 Homo sapiens