Title : cis-urocanic acid down-regulates the induction of adenosine 3',5'-cyclic monophosphate by either trans-urocanic acid or histamine in human dermal fibroblasts in vitro.

Pub. Date : 1992 Feb

PMID : 1311859






3 Functional Relationships(s)
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1 We report here that trans-UCA is biologically active in vitro in human dermal fibroblasts, inducing adenyl cyclase as measured by cAMP (adenosine 3",5"-cyclic monophosphate) formation in a dose-dependent manner similar to the action of histamine. Urocanic Acid cathelicidin antimicrobial peptide Homo sapiens
2 Cis-UCA does not increase cAMP in these human fibroblasts but actively down regulates the increase of cAMP induced by either histamine or trans-UCA. Urocanic Acid cathelicidin antimicrobial peptide Homo sapiens
3 The trans-UCA induction of cAMP can also be downregulated with an H2 histamine receptor antagonist cimetidine. Urocanic Acid cathelicidin antimicrobial peptide Homo sapiens