Title : In vitro and in vivo inhibition of rat liver aldehyde dehydrogenase by S-methyl N,N-diethylthiolcarbamate sulfoxide, a new metabolite of disulfiram.

Pub. Date : 1992 Feb 4

PMID : 1311578






1 Functional Relationships(s)
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1 It is therefore proposed that, based upon evidence to date, DETC-MeSO appears to be the chemical species to which disulfiram must be bioactivated, and is the metabolite most likely responsible for disulfiram"s inhibition of rat liver mitochondrial low Km ALDH in vivo. Disulfiram aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus