Pub. Date : 1992 Oct
PMID : 1308199
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phenytoin prevents stress- and corticosterone-induced atrophy of CA3 pyramidal neurons. | Corticosterone | carbonic anhydrase 3 | Rattus norvegicus |
| 2 | Repeated daily restraint stress and daily corticosterone administration to adult male Sprague-Dawley rats leads to decreases in the number of branch points and length of dendrites of CA3 pyramidal neurons of the hippocampal formation. | Corticosterone | carbonic anhydrase 3 | Rattus norvegicus |
| 3 | Stress- and corticosterone-induced effects on dendritic length and branch point number are more pronounced on the apical, as opposed to the basal, CA3 dendrites that receive the largest mossy fiber input from the dentate gyrus. | Corticosterone | carbonic anhydrase 3 | Rattus norvegicus |
| 4 | Because phenytoin is also known to prevent ischemic damage, these results are consistent with a model in which stress- and corticosterone-induced CA3 dendritic atrophy is produced by excitatory amino acids released from the mossy fibers. | Corticosterone | carbonic anhydrase 3 | Rattus norvegicus |