Title : Effects of DNA methylation on expression of tumor suppressor genes and proto-oncogene in human colon cancer cell lines.

Pub. Date : 2003 Sep

PMID : 12970888






1 Functional Relationships(s)
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1 In the cell lines of SW1116 and Colo-320, p16(INK4A) and APC mRNA expressions were obviously enhanced after treatment of either 10 micromol/L or 5 micromol/L 5-aza-dC for 24 h. However, no evidence was found that methylation regulated the expression of p21(WAF1) and c-myc genes in human colon cancer cell lines. Decitabine MYC proto-oncogene, bHLH transcription factor Homo sapiens