Title : Cell itinerary and metabolic fate of proinsulin in rat liver: in vivo and in vitro studies.

Pub. Date : 2003 Dec

PMID : 12970169






1 Functional Relationships(s)
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1 As native insulin, native proinsulin induced a dose- and time-dependent endocytosis and tyrosine phosphorylation of the insulin receptor; but at an inframaximal dose, proinsulin effects on these processes were of longer duration. Tyrosine insulin receptor Rattus norvegicus