Title : Increased sensitivity of the ryanodine receptor to halothane-induced oligomerization in malignant hyperthermia-susceptible human skeletal muscle.

Pub. Date : 2004 Jan

PMID : 12959958






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Mutations in the skeletal muscle RyR1 isoform of the ryanodine receptor (RyR) Ca2+-release channel confer susceptibility to malignant hyperthermia, which may be triggered by inhalational anesthetics such as halothane. Halothane ryanodine receptor 1 Homo sapiens
2 In the concentration range of 0.014-0.35 mM halothane, anesthetic-induced oligomerization of the RyR1 complex was observed at a lower threshold concentration in the sarcoplasmic reticulum from patients with malignant hyperthermia. Halothane ryanodine receptor 1 Homo sapiens