Title : Valproate disrupts regulation of inositol responsive genes and alters regulation of phospholipid biosynthesis.

Pub. Date : 2003 Sep

PMID : 12950923






2 Functional Relationships(s)
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1 Surprisingly, expression of genes that are usually derepressed during inositol depletion, including INO1, CHO1 and INO2 (that contain inositol-responsive UASINO sequences) decreased several fold during the first hour, after which expression began to increase. Inositol CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C
2 Surprisingly, expression of genes that are usually derepressed during inositol depletion, including INO1, CHO1 and INO2 (that contain inositol-responsive UASINO sequences) decreased several fold during the first hour, after which expression began to increase. Inositol CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C