Title : Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression.

Pub. Date : 2003 Nov 7

PMID : 12947090






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Treatment of HepG2 cells with the PKC inhibitors staurosporine and calphostin C repressed ARE-mediated induction of a luciferase reporter as well as that of the endogenous NQO1 gene. calphostin C proline rich transmembrane protein 2 Homo sapiens