Title : Pro-apoptotic effect of high concentrations of histamine on human neutrophils.

Pub. Date : 2003 Oct

PMID : 12946446






5 Functional Relationships(s)
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1 And, the protein kinase C (PKC)-delta inhibitor, rottlerin (5 microM) significantly blocked the apoptotic effect of histamine, though the cleavage of PKC-delta in 20 h cultured neutrophils was increased by histamine. Histamine protein kinase C delta Homo sapiens
2 And, the protein kinase C (PKC)-delta inhibitor, rottlerin (5 microM) significantly blocked the apoptotic effect of histamine, though the cleavage of PKC-delta in 20 h cultured neutrophils was increased by histamine. Histamine protein kinase C delta Homo sapiens
3 And, the protein kinase C (PKC)-delta inhibitor, rottlerin (5 microM) significantly blocked the apoptotic effect of histamine, though the cleavage of PKC-delta in 20 h cultured neutrophils was increased by histamine. Histamine protein kinase C delta Homo sapiens
4 These results suggest that high concentrations of histamine in local inflammatory and allergic lesions induce neutrophil apoptosis, and that this histamine-induced apoptosis is mediated by caspase activation and PKC-delta signaling. Histamine protein kinase C delta Homo sapiens
5 These results suggest that high concentrations of histamine in local inflammatory and allergic lesions induce neutrophil apoptosis, and that this histamine-induced apoptosis is mediated by caspase activation and PKC-delta signaling. Histamine protein kinase C delta Homo sapiens