Title : Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil.

Pub. Date : 2003 Sep 1

PMID : 12942110






2 Functional Relationships(s)
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1 The AUC(0-10 h) of uracil on day 5 was 252+/-60 ng h ml(-1) with PVI of 5-FU and 12 582+/-3060 ng h ml(-1) with S-1. Uracil proteasome 26S subunit, non-ATPase 1 Homo sapiens
2 The AUC(0-10 h) of FBAL was markedly lower and plasma uracil concentrations were significantly higher for S-1 than for PVI of 5-FU, clearly demonstrating the effect of DPD inhibition. Uracil proteasome 26S subunit, non-ATPase 1 Homo sapiens