Title : Regulatory role of cAMP on expression of Cdk4 and p27(Kip1) by inhibiting phosphatidylinositol 3-kinase in corneal endothelial cells.

Pub. Date : 2003 Sep

PMID : 12939297






4 Functional Relationships(s)
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1 The current study was designed to determine whether adenosine 3",5"-monophosphate (cAMP) antagonizes FGF-2 by inhibiting PI 3-kinase/Akt pathways, thus leading to regulation of cyclin-dependent kinase 4 (Cdk4) and p27(Kip1) (p27) expression. Cyclic AMP AKT serine/threonine kinase 1 Homo sapiens
2 The current study was designed to determine whether adenosine 3",5"-monophosphate (cAMP) antagonizes FGF-2 by inhibiting PI 3-kinase/Akt pathways, thus leading to regulation of cyclin-dependent kinase 4 (Cdk4) and p27(Kip1) (p27) expression. Cyclic AMP AKT serine/threonine kinase 1 Homo sapiens
3 RESULTS: 8-Bromoadenosine cAMP (8-Br-cAMP), a diffusible cAMP analogue, inhibited the PI 3-kinase/Akt signaling pathways. Cyclic AMP AKT serine/threonine kinase 1 Homo sapiens
4 RESULTS: 8-Bromoadenosine cAMP (8-Br-cAMP), a diffusible cAMP analogue, inhibited the PI 3-kinase/Akt signaling pathways. Cyclic AMP AKT serine/threonine kinase 1 Homo sapiens