Title : Inhibition of heme biosynthesis prevents transcription of iron uptake genes in yeast.

Pub. Date : 2003 Nov 14

PMID : 12928433






2 Functional Relationships(s)
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1 We demonstrated that under heme-depleted conditions, Aft1p-GFP was able to cycle normally between the nucleus and cytosol in response to cytosolic iron. Iron DNA-binding transcription factor AFT1 Saccharomyces cerevisiae S288C
2 Despite the inability to induce transcription under low iron conditions, chromatin immunoprecipitation demonstrated that Aft1p binds to the FET3 promoter in the absence of heme. Iron DNA-binding transcription factor AFT1 Saccharomyces cerevisiae S288C