Title : Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain.

Pub. Date : 2003 Sep 1

PMID : 12927873






2 Functional Relationships(s)
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1 Our previous screen of flavones and related heterocycles for the ability to activate the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel indicated that UCCF-029, a 7,8-benzoflavone, was a potent activator. alpha-naphthoflavone CF transmembrane conductance regulator Homo sapiens
2 Our previous screen of flavones and related heterocycles for the ability to activate the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel indicated that UCCF-029, a 7,8-benzoflavone, was a potent activator. alpha-naphthoflavone CF transmembrane conductance regulator Homo sapiens