Title : Ab initio QM/MM study shows there is no general acid in the reaction catalyzed by 4-oxalocrotonate tautomerase.

Pub. Date : 2003 Aug 27

PMID : 12926963






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 In the first step, Pro-1 acts as a general base to abstract a proton from the third carbon of the substrate, 2-oxo-4-hexenedioate, creating a negative charge on the oxygen at C-2 of this substrate. Carbon lamin A/C Homo sapiens
2 In the second step, the same hydrogen abstracted by the N-terminal Pro-1 is shuttled back to the fifth carbon of the substrate to form the product, 2-oxo-3-hexenedioate. Carbon lamin A/C Homo sapiens