Title : Application of compartmental modeling to an examination of in vitro intestinal permeability data: assessing the impact of tissue uptake, P-glycoprotein, and CYP3A.

Pub. Date : 2003 Sep

PMID : 12920171






1 Functional Relationships(s)
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1 Surprisingly, the selective P-gp inhibitor, valspodar (PSC833), had an insignificant impact on P-gp-mediated efflux of verapamil; however, selective CYP3A inhibition (afforded by midazolam) increased mucosal to serosal verapamil transport 1.6-fold, presumably through a reduction in intestinal metabolism. Midazolam cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus