Title : A derivative of the menaquinone precursor 1,4-dihydroxy-2-naphthoate is involved in the reductive transformation of carbon tetrachloride by aerobically grown Shewanella oneidensis MR-1.

Pub. Date : 2004 Feb

PMID : 12908086






4 Functional Relationships(s)
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Protein Name
Organism
1 The menB, menA and menG mutants are all blocked towards the end of the pathway, being unable to produce 1,4-dihydroxy-2-naphthoic acid (DHNA), demethyl-menaquinone and menaquinone, respectively. 1,4-dihydroxy-2-naphthoic acid 1,4-dihydroxy-2-naphthoyl-CoA synthase Shewanella oneidensis MR-1
2 The menB, menA and menG mutants are all blocked towards the end of the pathway, being unable to produce 1,4-dihydroxy-2-naphthoic acid (DHNA), demethyl-menaquinone and menaquinone, respectively. 1,4-dihydroxy-2-naphthoic acid 1,4-dihydroxy-2-naphthoyl-CoA synthase Shewanella oneidensis MR-1
3 Aerobically grown mutants unable to produce the menaquinone precursor DHNA (menF and menB mutants) showed a distinctly different CT transformation profile than mutants able to produce DHNA but unable to produce menaquinone (menA and menG mutants). 1,4-dihydroxy-2-naphthoic acid 1,4-dihydroxy-2-naphthoyl-CoA synthase Shewanella oneidensis MR-1
4 While DHNA did not reduce CT in an abiotic assay, the addition of DHNA to the menF and menB mutants restored normal CT transformation activity. 1,4-dihydroxy-2-naphthoic acid 1,4-dihydroxy-2-naphthoyl-CoA synthase Shewanella oneidensis MR-1