Pub. Date : 2003 Aug
PMID : 12887692
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ten of the 12 mGlu3 mutants (R64A, R68A, Y150A, S151A, T174A, D194A, Y222A, R277A, D301A and K389) showed either no binding or a 90% or greater loss of specific [3H]DCG-IV binding. | dcg | glutamate receptor, metabotropic 3 | Mus musculus |
| 2 | These results demonstrate that the binding of [3H]DCG-IV to mGlu3 is exceptionally sensitive to mutagenesis-induced perturbations. | dcg | glutamate receptor, metabotropic 3 | Mus musculus |
| 3 | In silico docking of DCG-IV into the agonist binding pocket of mGlu3 facilitated the interpretation the mutagenesis results. | dcg | glutamate receptor, metabotropic 3 | Mus musculus |