Pub. Date : 2003
PMID : 12881019
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Studies were conducted to determine whether tocotrienol-induced apoptosis is mediated by activation of the caspase-8 and/or caspase-9 pathway. | Tocotrienols | caspase 8 | Mus musculus |
| 2 | Furthermore, treatment with specific caspase-8 or -3 inhibitors, but not caspase-9 inhibitor, completely blocked the tocotrienol-induced apoptosis in +SA cells. | Tocotrienols | caspase 8 | Mus musculus |
| 3 | These findings demonstrate that tocotrienol-induced apoptosis in +SA mammary cancer cells is mediated through activation of the caspase-8 signaling pathway and is independent of caspase-9 activation. | Tocotrienols | caspase 8 | Mus musculus |