Title : The oncogene phosphatidylinositol 3'-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma.

Pub. Date : 2003 Jul 15

PMID : 12874030






2 Functional Relationships(s)
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1 In vitro, PIK3CA expression positively correlated with the expression of VEGF in ovarian cancer cells, whereas the phosphatidylinositol 3"-kinase inhibitor Ly294002 reduced both the constitutive and inducible expression of hypoxia-inducible factor-1alpha at the mRNA and protein levels and abrogated VEGF up-regulation by glucose starvation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one vascular endothelial growth factor A Homo sapiens
2 In vitro, PIK3CA expression positively correlated with the expression of VEGF in ovarian cancer cells, whereas the phosphatidylinositol 3"-kinase inhibitor Ly294002 reduced both the constitutive and inducible expression of hypoxia-inducible factor-1alpha at the mRNA and protein levels and abrogated VEGF up-regulation by glucose starvation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one vascular endothelial growth factor A Homo sapiens