Title : Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain.

Pub. Date : 2003 Jul

PMID : 12871572






1 Functional Relationships(s)
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1 BAF treatment reduced the activity of caspase-3, -2 and -9 (78, 73 and 33%, respectively), and prevented caspase-dependent fodrin cleavage in vivo, but did not affect AIF release from mitochondria or the frequency of positive nuclear AIF or DNA damage 72 h post-HI, indicating that these processes occurred in a caspase-independent fashion. butyloxycarbonyl-aspartyl-fluoromethyl ketone apoptosis inducing factor, mitochondria associated 1 Rattus norvegicus