Pub. Date : 2003 Aug
PMID : 12869633
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In p53-deficient cells, little K2-5F is expressed, and thus HSV-TK is expressed, allowing the cells to be killed by ganciclovir (GCV). | Ganciclovir | tumor protein p53 | Homo sapiens |
| 2 | In p53-deficient cells, little K2-5F is expressed, and thus HSV-TK is expressed, allowing the cells to be killed by ganciclovir (GCV). | Ganciclovir | tumor protein p53 | Homo sapiens |
| 3 | K2-5F induced by exogenous p53 dramatically reduced the expression of HSV-TK in human embryonic kidney 293 cells, and it subsequently increased cell survival in response to GCV. | Ganciclovir | tumor protein p53 | Homo sapiens |
| 4 | Stable expression of moderate levels of p53 in Saos-2 cells was able to induce the expression of K2-5F and reduce HSV-TK expression and resulted in a modest but distinct protection from GCV toxicity. | Ganciclovir | tumor protein p53 | Homo sapiens |