Title : Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.

Pub. Date : 2003 Aug 8

PMID : 12869392






2 Functional Relationships(s)
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Protein Name
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1 In the presence of 2.5 micromol/L 3-keto-hexadecanoyl CoA (KHCoA), trimetazidine resulted in a 50% inhibition of LC-3-KAT activity. 3-keto-hexadecanoyl coa thiosulfate sulfurtransferase like domain containing 1 Homo sapiens
2 However, the inhibition of LC 3-KAT could be completely reversed by increasing substrate (3-keto-hexadecanoyl CoA, KHCoA) concentrations to 15 micromol/L even at high concentrations of trimetazidine (100 micromol/L). 3-keto-hexadecanoyl coa thiosulfate sulfurtransferase like domain containing 1 Homo sapiens