Title : The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

Pub. Date : 2003 Aug 8

PMID : 12869391






2 Functional Relationships(s)
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1 Recent published data support the hypothesis that trimetazidine selectively inhibits long-chain 3-ketoacyl CoA thiolase (LC 3-KAT), thereby reducing fatty acid oxidation resulting in clinical benefit. Trimetazidine microtubule associated protein 1 light chain 3 alpha Homo sapiens
2 The aim of this study was to assess whether trimetazidine and ranolazine, which may also act as a metabolic modulator, are specific inhibitors of LC 3-KAT. Trimetazidine microtubule associated protein 1 light chain 3 alpha Homo sapiens