Title : Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids.

Pub. Date : 2003 Sep 26

PMID : 12865424






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Lauric acid induced the transient phosphorylation of AKT. lauric acid AKT serine/threonine kinase 1 Homo sapiens
2 These results demonstrate that NFkappaB activation and COX-2 expression induced by lauric acid are at least partly mediated through the TLR4/PI3K/AKT signaling pathway. lauric acid AKT serine/threonine kinase 1 Homo sapiens
3 In contrast, docosahexaenoic acid (DHA) inhibited the phosphorylation of AKT induced by lipopolysaccharide or lauric acid. lauric acid AKT serine/threonine kinase 1 Homo sapiens