Title : Phosphorylation site interdependence of human p53 post-translational modifications in response to stress.

Pub. Date : 2003 Sep 26

PMID : 12860987






2 Functional Relationships(s)
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1 Modification-specific antibodies were used to characterize the phosphorylation and acetylation of human p53 in response to genotoxic (UV, IR, and adriamycin) and non-genotoxic (PALA, taxol, nocodazole) stress in cultured human cells at 14 known modification sites. Nocodazole tumor protein p53 Homo sapiens
2 The non-genotoxic agents PALA, taxol and nocodazole induced p53 accumulation and phosphorylation at Ser6, Ser33, Ser46, and Ser392. Nocodazole tumor protein p53 Homo sapiens