Title : Effects of TNFalpha on the growth and sensitivity to cytosine arabinoside of blast progenitors in acute myelogenous leukemia with special reference to the role of NF-kappaB.

Pub. Date : 2003 Nov

PMID : 12859994






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Antisense oligodeoxynucleotides sensitized HL60 cells to Ara-C but rendered leukemic progenitors in patient samples even more resistant to Ara-C in the presence of TNFalpha and IL-3 in combination, indicating that NF-kappaB is involved in the Ara-C sensitivity of leukemic blast progenitors but may exert opposite dual functions, namely protection from and induction of apoptosis, under different conditions. Oligodeoxyribonucleotides interleukin 3 Homo sapiens