Pub. Date : 2003 Aug 1
PMID : 12859987
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 2 | The inhibitor of NQO1, dicumarol, protected against the toxicity of aziridinyl-benzoquinones except of 2,5-bis-(2"-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone (BZQ), which was almost inactive as NQO1 substrate. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 3 | These findings indicate that in addition to the activation by NQO1, the oxidative stress presumably initiated by single-electron transferring enzymes may be an important factor in the cytotoxicity of aziridinylbenzoquinones. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |